Clinical Management of Uveitis in Systemic Rheumatic Autoimmune Diseases in Adults - Sci Forschen

Article Information

Aritcle Type: Review Article

Citation: Chora I, Borges T, Dias C, Ourique C, Vilaça J, et al. (2015) Clinical Management of Uveitis in Systemic Rheumatic Autoimmune Diseases in Adults. Autoimmun Infec Dis 1(1): doi http://dx.doi.org/10.16966/aidoa.104

Copyright: © 2015 Chora I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Publication history:

 Received date: 19 July 2015

 Accepted date: 03 August 2015

 Published date: 10 August 2015


Authors :

 Inês Chora^*#      Tiago Borges^#     Carla Dias     Carolina Ourique      João Vilaça     Sara Ferreira     Paula Vaz-Marques      Sérgio Silva     Carlos Dias
Department of Internal Medicine, São João Hospital Center, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal^#The first two authors contributed equally to this work

*Corresponding author: Inês Chora, Department of Internal Medicine, São João Hospital Center, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal, E-mail: i_chora@yahoo.com


Abstract

Uveitis is an intraocular inflammation of multiple possible etiologies, making its clinical management particularly challenging. Autoimmune uveitis is a leading and under-recognized cause of preventable blindness. Systemic sarcoidosis, spondyloarthritis, Behçet’s syndrome and VogtKoyanagi-Harada’s syndrome are systemic autoimmune diseases frequently associated with uveitis.

A stepwise approach of autoimmune uveitis is essential to appropriate diagnosis and early treatment. When autoimmune uveitis is suspected, patients should be promptly referred to an ophthalmologist for the classification of ocular lesions; thereafter, a multidisciplinary investigation of a subjacent systemic disease must follow. Currently, no consensus diagnostic algorithm is accepted for autoimmune uveitis and an individualized approach is generally used. The treatment of autoimmune uveitis depends on ocular semiology, being further refined if an underlying systemic disorder is identified.

This review focuses on relevant clinical, diagnostic and therapeutic issues related to autoimmune uveitis in adults, with emphasis on the main associated systemic autoimmune diseases. A diagnostic algorithm for autoimmune uveitis is proposed.

Keywords

Autoimmune uveitis; Behçet’s syndrome; Sarcoidosis; Spondyloarthritis; Vogt-Koyanagi-Harada syndrome

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